Mr. Sidharth Mahapatra | Pediatrics | Best Researcher Award

Associate Professor at University of Nebraska Medical Center – UNMC, United States

Dr. Sidharth Mahapatra is a physician-scientist specializing in pediatric critical care medicine and pediatric neuro-oncology. He serves as an Associate Professor at the University of Nebraska Medical Center and Creighton University School of Medicine, where he directs research in the Division of Critical Care Medicine. His research explores molecular pathways in pediatric brain tumors and respiratory distress syndromes, with a strong focus on developing novel targeted therapies. Dr. Mahapatra has received numerous awards for clinical excellence, research innovation, and medical education, including the Hobart E. Wiltse Excellence in Medical Education Award (2023), the NCI Loan Repayment Award (2022), and multiple UNeMed Invention Contributor recognitions.

Publication Profile

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Educational Details

Dr. Sidharth Mahapatra earned his B.A. in Cellular/Molecular Biology from Knox College, Galesburg, IL, graduating Magna Cum Laude with an Honors Thesis under Mark R. Brodl. He pursued his M.D. and Ph.D. in Biochemistry/Molecular Biology at Rosalind Franklin University, North Chicago, IL, where he was inducted into Alpha Omega Alpha and conducted his Ph.D. research under Kenneth E. Neet.

Professional Experience

Dr. Mahapatra is an Associate Professor in the Department of Pediatrics and the Department of Biochemistry and Molecular Biology at the University of Nebraska Medical Center (UNMC), Omaha, NE. He also holds a faculty position as an Assistant Professor in Biomedical Sciences at Creighton University School of Medicine. Previously, he was an Assistant Professor in Pediatrics and Biochemistry & Molecular Biology at UNMC and Creighton University.

In addition to his academic roles, Dr. Mahapatra has been the Director for Research in the Division of Critical Care Medicine at UNMC since 2021, having previously served as Interim Director (2018–2020).

Research Interest

Dr. Mahapatra’s research focuses on pediatric neuro-oncology, medulloblastoma, and critical care medicine, particularly in pediatric acute respiratory distress syndrome (PARDS). His work involves the molecular mechanisms of tumor progression and metastasis, with a special interest in identifying novel therapeutic targets for pediatric brain tumors and other malignancies.

Author Metrics

Dr. Mahapatra has authored numerous high-impact publications, with a growing citation record in pediatric critical care and cancer research. Some of his notable publications include:

• “Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE)” – The Lancet Respiratory Medicine (2019) – 327 citations
• “Acute respiratory distress syndrome” – StatPearls [Internet] (2024) – 138 citations
• “MUC4 mucin—a therapeutic target for pancreatic ductal adenocarcinoma” – Expert Opinion on Therapeutic Targets (2017) – 85 citations
• “Disruption of C1galt1 gene promotes development and metastasis of pancreatic adenocarcinomas in mice” – Gastroenterology (2018) – 82 citations
• “microRNAs orchestrate pathophysiology of breast cancer brain metastasis: advances in therapy” – Molecular Cancer (2020) – 64 citations

Top Noted Publication

1. Paediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE): An International, Observational Study

• Authors: RG Khemani, L Smith, YM Lopez-Fernandez, J Kwok, R Morzov, MJ Klein, et al.
• Journal: The Lancet Respiratory Medicine
• Volume/Issue: 7(2), Pages 115-128
• Year: 2019
• Citations: 327
• DOI: 10.1016/S2213-2600(18)30344-8
• Summary: This international observational study examines the incidence and epidemiology of pediatric acute respiratory distress syndrome (pARDS). It provides insights into global variability, risk factors, and outcomes associated with pARDS in critically ill children.

2. Acute Respiratory Distress Syndrome

• Authors: M Diamond, HL Peniston, DK Sanghavi, S Mahapatra
• Journal: StatPearls [Internet]
• Year: 2024
• Citations: 138
• Access: Available on StatPearls database
• Summary: This review provides an updated understanding of acute respiratory distress syndrome (ARDS), covering its pathophysiology, clinical presentation, diagnostic criteria, and therapeutic approaches. It is a valuable reference for clinicians and researchers.

3. MUC4 Mucin—A Therapeutic Target for Pancreatic Ductal Adenocarcinoma

• Authors: SK Gautam, S Kumar, A Cannon, B Hall, R Bhatia, MW Nasser, et al.
• Journal: Expert Opinion on Therapeutic Targets
• Volume/Issue: 21(7), Pages 657-669
• Year: 2017
• Citations: 85
• DOI: 10.1080/14728222.2017.1337772
• Summary: This paper explores MUC4 mucin as a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC). It highlights the role of MUC4 in tumor progression, metastasis, and chemoresistance, emphasizing its potential as a novel treatment target.

4. Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

• Authors: S Chugh, S Barkeer, S Rachagani, RK Nimmakayala, N Perumal, et al.
• Journal: Gastroenterology
• Volume/Issue: 155(5), Pages 1608-1624
• Year: 2018
• Citations: 82
• DOI: 10.1053/j.gastro.2018.07.013
• Summary: This study investigates the role of the C1galt1 gene in pancreatic adenocarcinoma. The authors demonstrate that its disruption accelerates tumor progression and metastasis in mouse models, suggesting its potential as a biomarker or therapeutic target.

5. microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

• Authors: RK Kanchan, JA Siddiqui, S Mahapatra, SK Batra, MW Nasser
• Journal: Molecular Cancer
• Volume: 19, Pages 1-16
• Year: 2020
• Citations: 64
• DOI: 10.1186/s12943-020-01161-5
• Summary: This review discusses the role of microRNAs in breast cancer brain metastases, emphasizing their involvement in tumor progression, invasion, and therapeutic resistance. The paper explores emerging miRNA-based treatment strategies.

Conclusion