Ms. Shahrzad Manavi Nameghi | Biochemistry | Best Researcher Award

Researcher | Islamic Azad University Tehran Medical Sciences | Iran

Shahrzad Manavi Nameghi is an accomplished molecular genetics researcher from Tehran, Iran, recognized for her work in diabetes, cancer pathways, gene therapy, and stem cell research. She completed her M.Sc. in Molecular Biology-Genetics at Islamic Azad University, Tehran Medical Sciences in 2019, where her thesis focused on the relation between the GIPR gene and type 2 diabetes, following a B.Sc. in Cellular and Molecular Biology-Genetics from Shahid Bahonar University, Kerman in 2017. Professionally, she has served as a lab technician and R&D assistant at Khazar Lab, Tehran, and as a main lab technician at Mendel Medical Genetics Laboratory, contributing to projects involving DNA and RNA extraction, real-time PCR, pyro-sequencing, ARMS-PCR, MLPA-PCR, and other molecular techniques. She has also worked as a research assistant at the Endocrine and Metabolism Research Institute, gaining expertise in RFLP-PCR and sequencing analysis. Her research interests include molecular genetics, diabetes and cancer-related gene pathways, gene therapy, and stem cell therapy, and she is proficient in analytical techniques such as ELISA, fragment analysis, primer design, and basic R programming. Shahrzad has published multiple peer-reviewed articles in indexed journals including Gene Reports, Endocrine and Metabolic Science, and Regenerative Biology and Medicine, with a growing citation count of 15 and h-index of 2, and serves as an editor and peer reviewer for biomedical journals. She has presented her work at international conferences, including the IDF Congress in Korea and Brussels, and completed various certifications and workshops in peer review, manuscript preparation, laboratory techniques, and molecular biology. Her achievements, dedication to research, and involvement in scientific communities underscore her leadership potential and commitment to advancing biomedical science. For her significant contributions to molecular genetics, diabetes, and cancer research, and her active role in knowledge dissemination and mentorship, Shahrzad Manavi Nameghi is a highly deserving candidate for the Best Researcher Award.

Profiles: Google Scholar | ORCID | Scopus | LinkedIn | ResearchGate

Featured Publications

Manavi Nameghi, S. (2024). Unraveling the molecular genetic basis of type 2 diabetes. Journal of Gene Reports. CiteScore: 3.3. Citations: 4. H-index: 2.
Manavi Nameghi, S. (2024). Exploring the recent advancement and future prospects of personalized medicine in type 2 diabetes. Journal of Endocrine and Metabolic Science. CiteScore: 2.8.
Manavi Nameghi, S. (2023). Cancer stem cells as a considerable barrier in anti-cancer treatments. Journal of Regenerative Biology and Medicine. CiteScore: 7.
Manavi Nameghi, S. (2023). Association of GIPR gene variant on the risk of type 2 diabetes: A case control study. Journal of Endocrine and Metabolic Science. CiteScore: 2.8.
Manavi Nameghi, S. (2022). Investigating the highlights of pluripotent stem cells in type 2 diabetes. Journal of Regenerative Biology and Medicine. CiteScore: 7.

Dr. Dmitry Baytin | Biochemistry | Best Researcher Award

Senior Scientist at Peter the Great St. Petersburg Polytechnic University, Russia

Dr. Dmitry Baytin is a distinguished research scientist specializing in protein biochemistry, with a focus on RecA and SOS response proteins from various bacterial species. He holds a Ph.D. in biochemistry and a Doctor of Sciences degree, complemented by postdoctoral training in leading international laboratories. His expertise lies in DNA repair mechanisms, homologous recombination, and the molecular basis of antibiotic resistance, where he has made notable contributions through the development of innovative models and inhibitors targeting RecA activity. Dr. Baytin has authored more than 25 publications in high-impact journals, secured competitive research grants, and contributed to patented innovations. Currently serving as a senior researcher, he collaborates internationally, mentors young scientists, and advances fundamental discoveries with significant implications for combating antibiotic resistance and enhancing molecular biology research.

Professional Profile

Google Scholar

Education

Dr. Dmitry Baytin completed his Ph.D. in biochemistry at Saint Petersburg State University, where his doctoral research focused on the recombinogenic properties of RecA proteins and DNA-protein interactions. He later pursued advanced training as a postdoctoral researcher at the University of Nebraska Medical Center and Madison University, gaining expertise in molecular genetics and biochemical mechanisms of DNA repair. Building upon this foundation, he obtained his Doctor of Sciences degree at the Institute of Cytology, Russian Academy of Sciences, further strengthening his academic credentials and establishing his authority in protein biochemistry. His educational journey, spanning multiple prestigious institutions and international laboratories, provided him with a solid grounding in research methodologies, critical problem-solving, and innovative approaches that now underpin his extensive contributions to molecular biology and biochemistry.

Experience

Dr. Dmitry Baytin has built an accomplished career as a senior researcher, beginning as a research associate at the Petersburg Nuclear Physics Institute, where he developed strong expertise in DNA repair mechanisms and molecular genetics. He subsequently advanced into senior research positions, contributing significantly to projects in molecular and radiation biophysics, while collaborating with multidisciplinary teams on protein-DNA interactions. Currently, he serves as a senior researcher at Peter the Great St. Petersburg Polytechnic University, where his role encompasses leading scientific investigations, mentoring students, and contributing to institutional research excellence. His international research experiences in the United States, including work in highly regarded laboratories, enriched his professional expertise and enabled him to establish global scientific collaborations, demonstrating his ability to integrate fundamental research with applied perspectives to address pressing scientific and societal challenges.

Research Interest

Dr. Dmitry Baytin’s primary research interests lie in the biochemistry of DNA-binding proteins, with a strong focus on homologous recombination, RecA protein function, and SOS response regulation. His studies explore the molecular mechanisms of DNA strand exchange, the roles of regulatory proteins, and their implications in bacterial mutagenesis and antibiotic resistance. A major aspect of his work involves investigating RecX protein function and developing inhibitors of RecA activity to block the evolution of antibiotic resistance, an area of great biomedical and societal significance. He also engages in structural and functional studies of nucleoprotein complexes, utilizing advanced biochemical and biophysical methods. His interests extend to protein engineering, protein-protein and protein-DNA interactions, and the application of molecular insights to design therapeutic strategies, thereby bridging fundamental science with translational potential.

Award and Honor

Dr. Dmitry Baytin has received recognition for his impactful scientific contributions through competitive grants and awards. He has been a principal investigator on research projects funded by the Russian Foundation for Basic Research, supporting innovative studies in DNA repair mechanisms and protein biochemistry. His work has also been acknowledged through patents, including the development of a novel peptide inhibitor targeting RecA activity, reflecting both scientific and applied innovation. His international research collaborations, peer-reviewed publications in high-impact journals, and contributions to advancing molecular biology have further established his reputation in the global scientific community. These honors highlight his dedication, expertise, and commitment to addressing significant challenges in molecular biology and biomedical research, particularly in relation to combating the growing problem of antibiotic resistance.

Research Skills

Dr. Dmitry Baytin possesses advanced expertise in a wide range of molecular biology and biochemistry techniques. His skill set includes DNA gel shift assays, fluorescence-based electrophoresis, protein-DNA binding analysis, and fluorescence resonance energy transfer (FRET) to study molecular interactions. He is proficient in enzyme-coupled spectrophotometric assays for ATP hydrolysis, immunoblotting, SDS-PAGE, and single-molecule analysis of nucleoprotein complexes. Additionally, he has extensive experience with bacterial systems, using GFP-labeled fluorescence to monitor SOS responses in vivo. His methodological strength lies in integrating structural biology, protein engineering, and functional assays to uncover novel mechanisms of DNA repair and recombination. These versatile skills enable him to test protein-protein and protein-DNA interactions, evaluate compound effects on enzymatic activity, and develop innovative molecular strategies to address antibiotic resistance challenges.

Publication Top Notes

Title: A novel function of DNA polymerase ζ regulated by PCNA
Authors: MR Northam, P Garg, DM Baitin, PMJ Burgers, PV Shcherbakova
Year: 2006
Citation: The EMBO Journal, 25(18), 4316–4325

Title: Systematic search for structural motifs of peptide binding to double-stranded DNA
Authors: N Kolchina, V Khavinson, N Linkova, A Yakimov, D Baitin, A Afanasyeva, …
Year: 2019
Citation: Nucleic Acids Research, 47(20), 10553–10563

Title: Blocking the RecA activity and SOS-response in bacteria with a short α-helical peptide
Authors: A Yakimov, G Pobegalov, I Bakhlanova, M Khodorkovskii, M Petukhov, …
Year: 2017
Citation: Nucleic Acids Research, 45(16), 9788–9796

Title: Biochemical basis of hyper-recombinogenic activity of Pseudomonas aeruginosa RecA protein in Escherichia coli cells
Authors: EA Namsaraev, D Baitin, IV Bakhlanova, AA Alexseyev, H Ogawa, …
Year: 1998
Citation: Molecular Microbiology, 27(4), 727–738

Title: Efficient Strand Transfer by the RadA Recombinase from the Hyperthermophilic Archaeon Desulfurococcus amylolyticus
Authors: YV Kil, DM Baitin, R Masui, EA Bonch-Osmolovskaya, S Kuramitsu, …
Year: 2000
Citation: Journal of Bacteriology, 182(1), 130–134

Title: Targeting evolution of antibiotic resistance by SOS response inhibition
Authors: A Yakimov, I Bakhlanova, D Baitin
Year: 2021
Citation: Computational and Structural Biotechnology Journal, 19, 777–783

Title: Analytical model for determination of parameters of helical structures in solution by small angle scattering: comparison of RecA structures by SANS
Authors: DV Lebedev, DM Baitin, AK Islamov, AI Kuklin, VK Shalguev, VA Lanzov, …
Year: 2003
Citation: FEBS Letters, 537(1–3), 182–186

Title: Structure of RecX protein complex with the presynaptic RecA filament: Molecular dynamics simulations and small angle neutron scattering
Authors: AV Shvetsov, DV Lebedev, DB Chervyakova, IV Bakhlanova, IA Yung, …
Year: 2014
Citation: FEBS Letters, 588(6), 948–955

Title: Modulating cellular recombination potential through alterations in RecA structure and regulation
Authors: IV Bakhlanova, AV Dudkina, DM Baitin, KL Knight, MM Cox, VA Lanzov
Year: 2010
Citation: Molecular Microbiology, 78(6), 1523–1538

Title: SSB antagonizes RecX-RecA interaction
Authors: DM Baitin, MC Gruenig, MM Cox
Year: 2008
Citation: Journal of Biological Chemistry, 283(21), 14198–14204

Title: Hyper-recombinogenic RecA protein from Pseudomonas aeruginosa with enhanced activity of its primary DNA binding site
Authors: DM Baitin, EN Zaitsev, VA Lanzov
Year: 2003
Citation: Journal of Molecular Biology, 328(1), 1–7

Title: Deinococcus radiodurans RecA nucleoprotein filaments characterized at the single-molecule level with optical tweezers
Authors: G Pobegalov, G Cherevatenko, A Alekseev, A Sabantsev, O Kovaleva, …
Year: 2015
Citation: Biochemical and Biophysical Research Communications, 466(3), 426–430

Title: Distinguishing Characteristics of Hyperrecombinogenic RecA Protein from Pseudomonas aeruginosa Acting in Escherichia coli
Authors: DM Baitin, IV Bakhlanova, YV Kil, MM Cox, VA Lanzov
Year: 2006
Citation: Journal of Bacteriology, 188(16), 5812–5820

Title: Fluorescence and excitation Escherichia coli RecA protein spectra analyzed separately for tyrosine and tryptophan residues
Authors: VV Isaev-Ivanov, MG Kozlov, DM Baitin, R Masui, S Kuramitsu, VA Lanzov
Year: 2000
Citation: Archives of Biochemistry and Biophysics, 376(1), 124–140

Title: Two RecA protein types that mediate different modes of hyperrecombination
Authors: DM Baitin, IV Bakhlanova, DV Chervyakova, YV Kil, VA Lanzov, MM Cox
Year: 2008
Citation: Journal of Bacteriology, 190(8), 3036–3045

Conclusion

Dr. Dmitry Baytin stands as a highly accomplished scientist whose career exemplifies dedication to advancing molecular biochemistry and DNA repair research. Through his impactful publications, patents, international collaborations, and leadership in research, he has contributed significantly to the understanding of protein-DNA interactions and the molecular mechanisms of antibiotic resistance. His ability to combine fundamental discoveries with applied solutions demonstrates his relevance not only in academic science but also in addressing urgent global health issues. With strong research skills, extensive mentoring experience, and a proven record of innovation, Dr. Baytin is well-positioned to continue driving impactful scientific breakthroughs. His expertise, vision, and leadership potential make him a highly deserving candidate for recognition through the Best Researcher Award.