John Byrnes | Biochemistry, Genetics and Molecular Biology | Best Paper Award

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Best Paper Award

Selective Inhibition of Proofreading Exonucleases The Central Role in Obesity Assoviated Carciniogenesis
John Byrnes
Affiliation University of Miami
Country United States
Article Title Selective Inhibition of Proofreading Exonucleases The Central Role in Obesity Assoviated Carciniogenesis
Google Scholar ID 1kizaHgAAAAJ&hl
Article Type Research Article
Article Views 870
Reference Count 88
Award Category Best Paper Award
Event International Research Excellence and Best Paper Awards
ORCID 0000-0003-0940-9710

The Best Paper Award recognizes the scholarly contribution of John Byrnes of the University of Miami for research examining the relationship between proofreading exonucleases and obesity-associated carcinogenesis. Published in MDPI during 2026, the study contributes to ongoing discussions in biochemistry, genetics, and molecular biology regarding genomic integrity, cancer development, and molecular mechanisms associated with metabolic disorders. The award acknowledges the scientific significance, methodological rigor, and interdisciplinary relevance of the publication within contemporary biomedical research.[1]

Abstract

This award-recognized research investigates the potential role of proofreading exonucleases in mechanisms associated with obesity-related carcinogenesis. The study explores how alterations in DNA replication fidelity, repair pathways, and genomic maintenance may contribute to cellular transformation under metabolic stress conditions. Through molecular and biochemical analyses, the research evaluates the consequences of selective exonuclease inhibition and its implications for tumor development. Findings provide insights into interactions between obesity-associated biological environments and genomic instability. The work advances understanding of cancer biology while identifying potential molecular targets for future therapeutic development and translational biomedical investigations.[2]

Keywords

AMP; AMPK; carcinogenesis; DNA polymerase; fidelity; energy regulation; metabolism; mutation; obesity; proofreading exonuclease.

Introduction

The increasing prevalence of obesity has intensified scientific interest in understanding its relationship with cancer risk and progression. Researchers have identified multiple biological pathways linking metabolic dysregulation to genomic instability. This study focuses on proofreading exonucleases, enzymes responsible for maintaining DNA replication accuracy, and evaluates their relevance within obesity-associated carcinogenic processes that may influence disease initiation and progression.[2]

Research Profile

John Byrnes is affiliated with the University of Miami and has established a research portfolio within biochemistry, genetics, and molecular biology. With 138 indexed scholarly documents, 8,573 citations, and an h-index of 39, his academic contributions demonstrate sustained engagement in molecular mechanisms underlying human disease, cancer development, and genomic maintenance processes across diverse biomedical research domains.[3]

Scientific Background

Proofreading exonucleases play a critical role in correcting replication errors and preserving genome integrity. Deficiencies in these enzymatic systems can result in elevated mutation rates and increased susceptibility to malignant transformation. Previous investigations have linked obesity-related inflammation, oxidative stress, and metabolic disturbances with DNA damage, creating a scientific basis for examining interactions between exonuclease activity and carcinogenic pathways.[4]

Methodology

The research applies molecular biology and biochemical methodologies to investigate the consequences of selective proofreading exonuclease inhibition. Experimental analyses assess cellular responses, genomic integrity markers, and mechanisms associated with DNA repair regulation. By integrating laboratory observations with established cancer biology frameworks, the study evaluates how altered proofreading functions may contribute to carcinogenic processes under obesity-associated physiological conditions.[2]

Key Findings

The study identifies significant relationships between proofreading exonuclease activity and mechanisms that influence genomic stability. Results indicate that disruptions in proofreading functions may enhance mutation accumulation and contribute to cellular environments favorable to carcinogenesis. The findings support the hypothesis that obesity-associated biological stressors can interact with genomic maintenance pathways, potentially increasing cancer susceptibility through complex molecular mechanisms.[2]

Scientific Contributions

This research contributes to the growing body of knowledge connecting metabolic disease and cancer biology. By highlighting proofreading exonucleases as important molecular components within obesity-associated carcinogenesis, the study offers a framework for future investigations into diagnostic biomarkers and therapeutic interventions. The work also strengthens interdisciplinary connections between molecular genetics, oncology, and translational biomedical science.[4]

Conclusion

The Best Paper Award recognizes a publication that advances understanding of molecular mechanisms underlying obesity-associated cancer development. Through examination of proofreading exonucleases and genomic stability pathways, the research provides valuable scientific insights with potential relevance to future therapeutic strategies. Its contribution to contemporary biomedical literature reflects both methodological rigor and significance within the broader field of molecular oncology.[5]

References

  1. MDPI. (2026). Selective Inhibition of Proofreading Exonucleases The Central Role in Obesity Assoviated Carciniogenesis.
    https://www.mdpi.com/1467-3045/48/4/346
  2. DOI Reference. Cell Biochemistry and Function, Volume 48, Issue 4.
    https://doi.org/10.3390/cimb48040346
  3. Google Scholar. (n.d.). John Byrnes Author Profile.
    https://scholar.google.com/citations?user=1kizaHgAAAAJ&hl=en&oi=sra
  4. MDPI. (2026). Journal Information and Publication Metadata.
    https://www.mdpi.com/
  5. International Research Excellence and Best Paper Awards. (2026). Best Paper Award Recognition Program.
    https://bestpaperawards.com/

Rawad Sweidan | Agricultural and Biological Sciences | Editorial Board Member

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Mr. Rawad Sweidan | Agricultural and Biological Sciences | Editorial Board Member

Researcher | National Agricultural Research Center | Jordan

Rawad Sweidan is a researcher at the Livestock Research Directorate, National Agricultural Research Center, with a focus on ruminant nutrition and livestock production, particularly in sheep and camel breeds. His work has garnered 57 citations to date, reflecting his growing influence in animal science and agricultural research, with an h-index of 4 and i10-index of 2. Sweidan’s research spans from applied animal husbandry practices to plant-based interventions in livestock health. Notably, he investigated the effects of castration on the growth performance and carcass characteristics of Awassi lambs fed high-concentrate diets, a study cited 32 times, which provides critical insights for optimizing meat production efficiency in small ruminants. More recently, he has explored the use of willow (Salix spp.) extracts as a natural means to inhibit coccidia sporulation in goats, reflecting his interest in sustainable and herbal approaches to animal health. His work on willow silage for fattening Awassi lambs further illustrates his commitment to integrating locally available plant resources into livestock feeding strategies. Sweidan has also contributed to understanding the genetic uniqueness of the Alia camel in Jordan, emphasizing the importance of conserving and utilizing indigenous breeds for food security. Beyond livestock nutrition, he has participated in broader regional projects, such as the Enhancing Food Security in Arab Countries initiative, evaluating the adoption and impacts of agricultural interventions across Egypt, Jordan, Morocco, Sudan, and Tunisia. Additionally, he has co-authored studies on herbal medicine as natural alternatives for avian coccidiosis control, highlighting his multidisciplinary approach bridging animal nutrition, health, and sustainable agricultural practices. Collectively, Sweidan’s work demonstrates a dedication to improving livestock productivity, promoting animal health through natural and cost-effective strategies, and supporting food security initiatives in the Arab region, making him a notable contributor to both practical and scientific advancements in ruminant nutrition and agricultural sustainability.

Profile: Google Scholar

Featured Publications

  1. Haddad, S. G., Husein, M. Q., Sweidan, R. W. (2006). Effects of castration on growth performance and carcass characteristics of Awassi lambs fed high concentrate diet. Small Ruminant Research, 65(1-2), 149-153.

  2. Muklada, H., Davidovich-Rikanati, R., Wilkerson, D. G., Klein, J. D., Sweidan, R., et al. (2020). Genotypic diversity in willow (Salix spp.) is associated with chemical and morphological polymorphism, suggesting human-assisted dissemination in the Eastern Mediterranean. Biochemical Systematics and Ecology, 91, 104081.

  3. Haj-Zaroubi, M., Mattar, N., Awabdeh, S., Sweidan, R., Markovics, A., Klein, J. D., et al. (2024). Willow (Salix acmophylla Boiss.) leaf and branch extracts inhibit in vitro sporulation of coccidia (Eimeria spp.) from goats. Agriculture, 14(5), 648.

  4. Awabdeh, S., Sweidan, R., Landau, S. Y. (2022). Growth performance and carcass characteristics of fattening Awassi lambs fed willow silage. Small Ruminant Research, 215, 106758.

  5. Sweidan, R. W., Hayajneh, F. M., Awabdeh, S. A., Al-Nsour, S. S. (2025). Herbal medicine: A natural alternative treatment of avian coccidiosis. International Journal of Agriculture and Biosciences, 14(5), 811-817.

Rawad Sweidan’s research advances sustainable livestock nutrition and animal health by integrating plant-based solutions and optimizing indigenous breeds, directly supporting food security and agricultural innovation in the Arab region. His work bridges science and practice, promoting eco-friendly strategies that benefit society, industry, and global livestock management.

M M Abdullah Al Mamun Sony | Social Sciences | Best Researcher Award | 10112

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Mr. M M Abdullah Al Mamun Sony | Social Sciences | Best Researcher Award

Research Associate | ChangeMaker Nexus Ltd | Bangladesh

Mr. M.M. Abdullah Al Mamun Sony is an accomplished researcher and academic specializing in sociology, disaster management, gender studies, and social-environmental research. He is currently pursuing a Ph.D. at the University of Debrecen, Hungary, at the Géza Marton Doctoral School of Legal Studies with an outstanding grade of 4.98/5.00, reflecting his strong academic capabilities and commitment to research excellence. Sony holds a Master of Social Science in Sociology from Khulna University, Bangladesh, where he specialized in disaster management, gender policy, and sociological research methods, and a Bachelor of Social Science (Honours) in Sociology, also from Khulna University, demonstrating a solid academic foundation. His professional experience spans several significant roles, including Locally-led Action Research Consultant for the Bangladesh Preparedness Partnership, DOSZ Ambassador of Bangladesh fostering scientific collaboration with Hungary, and research associate and consultant for multiple social science and disaster management projects funded by Khulna University Research Cell, UGC Bangladesh, and international agencies. His research interests encompass social-environmental risk assessment, disaster coping mechanisms, gender-based studies, education quality, and labor market inclusion. Sony has developed strong research skills in quantitative and qualitative methods, including SPSS, NVivo, Atlas.ti, EndNote, and advanced data collection, analysis, and reporting techniques. He has an impressive publication record in Q1 and SSCI-indexed journals such as Social Sciences & Humanities Open, Sustainability, and the International Journal of Disaster Risk Reduction, with 22 citations, 7 documents, and an H-index of 3. Sony has received multiple awards and honors, including the Stipendium Hungaricum PhD Fellowship, Bangladesh Sweden Trust Fund travel grant, Best Leadership Award, Best Youth Icon Award, and recognition for outstanding presentations at international conferences. With his academic excellence, extensive research experience, international collaborations, leadership roles, and community engagement, Mr. M.M. Abdullah Al Mamun Sony demonstrates exceptional potential to contribute significantly to global social science research, making him a highly deserving candidate for recognition and awards in the field.

Profiles: Google Scholar | Scopus | ORCID | LinkedIn | ResearchGate

Featured Publications

  1. Yu, X., Amin, M. B., Olga, P., Rahaman, M. A., & Sony, M. M. A. A. M. (2024). Gender-based emergency response and crisis management knowledge assessment: A cross-sectional study on Chinese tertiary student. International Journal of Disaster Risk Reduction, 112, 104800. [Citations: 18]

  2. Mollah, M. A., Rana, M., Amin, M. B., Sony, M. M. A. A. M., Rahaman, M. A., & Fenyves, V. (2024). Examining the role of AI-augmented HRM for sustainable performance: Key determinants for digital culture and organizational strategy. Sustainability, 16(24), 10843. [Citations: 15]

  3. Roy, T., Chandra, D., Sony, M. M. A. A. M., & Rahman, M. S. (2021). Impact of salinity intrusion on health of coastal people: Reflections from Dacope upazila of Khulna district, Bangladesh. Khulna University Studies, 17(1 & 2), 57-66. [Citations: 14]

  4. Roy, T., Nasreen, M., Hasan, M. K., & Sony, M. M. A. A. M. (2023). Community priorities in disaster risk reduction interventions: A critical perspective from Bangladesh. In Coastal disaster risk management in Bangladesh (pp. 335-355). [Citations: 8]

  5. Hasan, M. K., & Sony, M. M. A. A. M. (2023). Covid-19, social change, and society 5.0. In The Palgrave Handbook of Global Social Change (pp. 1-19). [Citations: 8]

Mr. MD Shadman Soumik | Computer Science | Best Researcher Award

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Mr. MD Shadman Soumik | Computer Science | Best Researcher Award

Graduate Student | Washington University of Science & Technology | United States

MD Shadman Soumik is a dedicated IT Support and Data Security professional and researcher with extensive expertise in cybersecurity, data analytics, cloud computing, and enterprise IT systems, combining practical experience with innovative research contributions. He earned his Master of Science in Information Technology from Washington University of Science and Technology, Virginia (2025) and a Bachelor of Science in Electrical and Electronic Engineering from North South University, Bangladesh (2017), establishing a strong academic foundation for both technical and analytical proficiency. Over his career, he has worked with organizations including Reliable Home Care Services Corp, Frontier Semiconductor Bangladesh Ltd, and Poran Agro Products Ltd, where he provided comprehensive IT support, implemented cybersecurity protocols, conducted security audits, managed secure data integration, and optimized IT operations to ensure operational efficiency and data protection. His research interests encompass artificial intelligence applications in cybersecurity, network intrusion detection, secure and usable system design, early disease diagnosis using healthcare data, and AI-based financial market prediction. Soumik’s research skills include machine learning, neural networks, cybersecurity operations, database management, cloud computing, data analysis, technical writing, and project management, allowing him to bridge applied IT work and academic research effectively. He has contributed to high-impact publications in journals and conferences such as IEEE ICDSIS, International Journal of Computer Applications (IJCA), International Journal of Scientific Research and Applications (IJSRA), and International Journal of Advanced Research in Science, Communication and Technology (IJARSCT), and he actively participates in professional organizations including the International Society for Data Science and Analytics (USA) and the Institute of Engineers, Bangladesh. His achievements have been recognized through research awards and professional honors that highlight his contributions to cybersecurity, IT management, and applied analytics. In conclusion, MD Shadman Soumik exemplifies a researcher and professional whose combined expertise, leadership, publications, and dedication to innovation make him highly deserving of recognition, with significant potential to advance IT security, artificial intelligence applications, and data analytics on a global scale.

Profile: LinkedIn

Featured Publications

  1. Soumik, M. S., Mahmud, M. R., Sami, S. I., & Tanim, M. K. B. S. (2025). Designing secure and usable systems: The intersection of human-computer interaction, cybersecurity, and machine learning. International Journal of Computer Applications (IJCA).

  2. Tarafdar, R., Soumik, M. S., & Venkateswaranaidu, K. (2025). Applying artificial intelligence for enhanced precision in early disease diagnosis from healthcare dataset analytics. IEEE International Conference on Data Science and Information Systems (ICDSIS).

  3. Soumik, M. S. (2024). A comparative analysis of network intrusion detection (NID) using artificial intelligence techniques for increased network security. International Journal of Scientific Research and Applications (IJSRA).

  4. Tanim, M. K. B. S., Parash, M. H., Soumik, M. S., & Shakib, M. (2024). Enhanced network anomaly detection using convolutional neural networks in cybersecurity operations. International Journal of Computer Applications (IJCA).

  5. Soumik, M. S. (2024). Prediction of the financial stock market: A comprehensive analysis of artificial intelligence. International Journal of Advanced Research in Science, Communication and Technology (IJARSCT), 4(2).